Physiologically, after the loss of pregnancy, a woman’s body is quickly ready for a new reproductive cycle. Doctors usually recommend contraception for 6 months after a miscarriage, why? Loss of pregnancy and subsequent curettage of the uterus can cause the development of inflammatory diseases of the genital organs, adhesions, pathology of the uterus and tubes. In six months, all the inflammatory changes caused by a disturbed pregnancy will definitely subside and there is time to conduct an examination, to suggest and eliminate a possible cause of miscarriage.
When examining before the next pregnancy, it is important to do the following:
to clarify the presence or absence of hereditary diseases or genetic predisposition to miscarriage
identify the presence of inflammatory diseases and treat.
Genes and risks
Polymorphisms in some genes are related to miscarriage. Polymorphisms are, in simple terms, varieties of a single gene. These are not mutations (“breakdowns”), but variants of the norm. However, they can determine an increased propensity for some kind of disease or health condition.
For pregnancy, polymorphisms associated with the development of blood clotting disorders, the exchange of folates (folic acid compounds) are important.
Thrombophilia is a tendency to excessive thrombosis. It is important to understand: genetic analysis will tell us about a predisposition to thrombosis, but in order for this predisposition to materialize, additional risk factors are needed. Pregnancy is one of the risk factors. You can take measures in advance and prevent deep vein thrombosis during pregnancy by passing a genetic blood test in advance.
This important folate metabolism
Folic acid is a vitamin B9 that we must get from food. It is irreplaceable as it ensures cell division and growth, as well as reproduction of their genetic material. Folates are compounds of folic acid with which it enters the body. Ideally, all folate is converted in the body to a special form of 5-MTHF.
If the conversion of folates to the desired form is difficult, then fetal cell division disorders may occur, and the content of homocysteine in the blood, a substance that provokes thrombus formation, may also increase.
Knowing the genetic characteristics of the folate cycle enzymes can provide the body with the right forms of folate and prevent pregnancy complications.
How to find out?
The safest thing to do at the planning stage is to take a blood test for polymorphisms of some genes.
Laboratory research Genetic risk of pregnancy complications and fetal pathology (F2, F5, F7, FGB, F13A1, SERPINE1, ITGA2, ITGB3, MTHFR, MTR, MTRR – 12 points) will reveal polymorphisms in the genes responsible for thrombophilia and folate metabolism disorders. You can donate blood during the day
Research is important to do:
women planning a child;
women who have already had miscarriages or pregnancy complications;
men and women who have children with fetal malformations;
everyone who has had cases of thrombosis, heart attacks and strokes in the family up to 50 years old.
You can take tests either as directed by your doctor or on your own.